If you are curious about the latest in non-surgical facial rejuvenation, you are not alone. PRFM (Platelet-Rich Fibrin Matrix) is sought after by the patients as a top choice seeking natural, long-lasting results—without the downtime or risks of surgery. This blog covers various aspects of PRFM, from how it works to what you can expect before, during, and after your treatment.

PRFM stands for Platelet-Rich Fibrin Matrix. It’s an advanced regenerative treatment derived from your own blood. Unlike traditional platelet-rich plasma (PRP), PRFM is processed on-site to create a fibrin matrix to hold higher concentration of platelets and growth factors. PRFM allows for a paced release over time of these natural healing components, resulting in more effective and longer-lasting rejuvenation and better results overall for the patient and condition that is being treated.

The process is simple, safe, and minimally invasive:

1. A small amount of your blood is drawn which is very similar to what you may experience during a routine blood test.
2. The blood is spun in a specialized centrifuge to separate and concentrate the platelets and growth factors, while removing almost all red and white blood cells leaving behind a golden looking substance at the bottom of the test tube - PRFM.
3. PRFM is injected into targeted areas of your face or scalp or other areas using fine needles.

Because PRFM is made from your own blood the likelihood of an allergic reaction is close to zero allowing for a natural solution to address the treatment needs of the patient.

PRFM is versatile and can address a range of concerns, including:

• Under-eye hollows and dark circles
• Fine lines and wrinkles
• Acne scars and uneven skin texture
• Sagging or crepey skin
• Loss of facial volume
• Sun damage
• Thinning hair and hair loss (when injected into the scalp)

For patients looking for a natural way to refresh appearance, PRFM may be the perfect solution.

While both PRFM and PRP use your own platelets to stimulate healing, PRFM is the next generation. Here’s why:

• Higher concentration of growth factors: PRFM contains more platelets and growth factors than PRP, which means more powerful regeneration.
• Longer-lasting results: The fibrin matrix in PRFM allows for a sustained release of growth factors over days or even weeks, compared to just hours with PRP.
• No additives: PRFM is processed without chemicals or blood thinners, making it a 100% natural treatment.

At The Pur Health, your comfort and safety are our top priorities. Here’s what you can expect:

1. Consultation: We discuss your goals, assess your skin, and determine if PRFM is right for you.
2. Preparation: A topical numbing cream may be applied for comfort.
3. Blood Draw & Processing: We draw a small sample of blood and process it on-site.
4. Injection: The PRFM is carefully injected into the areas you want to improve.

Most treatments take about an hour, and you can return to your daily routine right away.

PRFM is known for minimal downtime. You might notice mild redness, swelling, or a tight feeling for a day or two. Some patients experience slight bruising or peeling, especially if combined with microneedling. These effects are temporary and resolve quickly.

To get the best results, we recommend:

• Drinking plenty of fluids
• Avoiding vigorous exercise for 24 hours
• Following any personalized aftercare instructions

PRFM works gradually, stimulating your body’s own collagen and elastin production. Most patients notice an improvement in skin texture and volume within 3–6 weeks, with continued enhancement over 3–4 months. Results can last 6–12 months or more, depending on your age, skin health, and lifestyle.

For optimal results, a series of 2–3 treatments spaced about a month apart is usually recommended.

Absolutely. Since PRFM is made from your own blood, there’s virtually no risk of allergic reaction or rejection. Side effects are mild and temporary, making it an excellent option for those seeking natural rejuvenation.

You may be a great candidate for PRFM if you:

• Want to address fine lines, wrinkles, or volume loss naturally
• Have under-eye hollows, acne scars, or thinning hair
• Prefer a treatment with minimal downtime and no synthetic ingredients
• Are in good general health

Let us know if you’re taking blood thinners or have any blood disorders, as this may affect your treatment plan.

At The Pur Health, your treatment is always performed by a medical doctor—never a rushed medspa injector. We take time to:

• Understand your unique goals and anatomy
• Customize your PRFM plan for natural, beautiful results
• Ensure your comfort and safety at every step

Whether you’re new to regenerative treatments or looking to maintain your youthful glow, we’re here to guide you with expertise and care.

f you’re ready for a fresh, natural look that lasts, PRFM could be your answer. Book your consultation at The Pur Health in Irvine, CA, and discover the next generation in facial rejuvenation.