Hormone Imbalance Symptoms in Women: Causes, Tests and What Helps
Medically reviewed by Sabeen Munib M.D.
Common hormone imbalance symptoms in women include irregular periods, unexplained weight gain, tiredness, mood swings, poor sleep, acne, hair changes and low libido. These symptoms usually come from a specific, treatable condition, most often a thyroid problem, polycystic ovary syndrome (PCOS), perimenopause, low progesterone, high prolactin or insulin resistance. The right blood tests, timed to the days of your cycle when needed, are how a doctor tells these hormone imbalances apart.
What is a hormone imbalance?
A hormone imbalance means one of your hormones is running too high or too low for your age and stage of life, and it is causing symptoms. Hormones are chemical messengers made by glands such as the thyroid, ovaries, pituitary, pancreas and adrenal glands. They affect your menstrual cycle, metabolism, brain, sleep, mood, skin, hair and weight, and their levels shift naturally over the months and years of your life.
A hormonal imbalance is not a diagnosis on its own; it is a starting point. Doctors look for the specific condition behind the symptoms, because a thyroid problem, PCOS and perimenopause can feel alike but need very different treatment. Hormone levels also change normally throughout life, during each monthly cycle, in pregnancy, after childbirth and in the years around menopause.
What are the most common hormone imbalance symptoms in women?
The most common signs of a hormonal imbalance in women are:
- Irregular periods, missed periods, or periods that become much heavier or lighter.
- Unexplained weight gain, especially around the belly, or weight loss you cannot explain.
- Tiredness that does not improve with rest.
- Mood swings, anxiety, irritability or depression.
- Trouble sleeping, hot flashes or night sweats.
- Acne, oily skin, or new hair growth on the face, chest or belly.
- Hair loss or thinning on the scalp.
- Low libido or vaginal dryness.
- Brain fog, poor focus or forgetfulness.
- Headaches that follow your menstrual cycle.
None of these symptoms on its own proves a hormone problem. Low iron, a few weeks of poor sleep, stress, low mood, medicines and many other health issues cause the same changes, which is why testing matters more than a symptom checklist.
What conditions cause hormone imbalance in women?
Thyroid problems
Thyroid disease is one of the most common causes of hormone imbalance symptoms in women, and it is easy to check with a TSH blood test. An underactive thyroid (hypothyroidism) can cause tiredness, weight gain, feeling cold, constipation, dry skin, hair thinning, depression and heavy or irregular periods. An overactive thyroid (hyperthyroidism) can cause weight loss, anxiety, a racing heart, feeling hot, sweating, poor sleep and lighter periods. Both are treatable, and thyroid hormones usually return to range within weeks to months of starting medicine.
Polycystic ovary syndrome (PCOS)
PCOS, also called polycystic ovarian syndrome, is the most common hormone condition in women of reproductive age. It is diagnosed when at least 2 of 3 features are present: irregular or missing periods, signs of high androgens (acne, extra hair growth, scalp hair thinning, or a high testosterone level), and polycystic ovaries on ultrasound. Many women with PCOS also have insulin resistance, weight gain, and a higher risk of type 2 diabetes, high cholesterol, depression and anxiety. Other causes, such as thyroid disease and high prolactin, are ruled out first.
Read about PCOS treatment at The Pur Health
Perimenopause and menopause
Perimenopause is the most common cause of new hormone symptoms in women in their 40s. It usually starts in the 40s and lasts about 4 to 8 years, ending at menopause, which comes at an average age of 51. Estrogen rises and falls unpredictably and progesterone drops, which can cause irregular periods, hot flashes, night sweats, poor sleep, mood changes, brain fog and vaginal dryness. Menopause before age 40 is called premature ovarian insufficiency and always needs testing.
Read more about perimenopause and its symptoms
Low progesterone
Progesterone is made mainly after ovulation, so low progesterone usually means you are not ovulating regularly. This is common in perimenopause, PCOS, thyroid disease and with large changes in weight, stress or exercise. It is especially common after age 40. Signs include unpredictable or heavy periods, spotting before a period and trouble getting pregnant.
Read about low progesterone symptoms
High prolactin
Prolactin is the hormone that tells the breasts to make milk. When it is high outside of pregnancy and the months of breastfeeding, it can stop ovulation and cause missed or unpredictable periods, milky nipple discharge, low libido and trouble getting pregnant. Common causes include some medicines (certain antipsychotics and anti-nausea drugs), an underactive thyroid and a small, usually noncancerous pituitary growth. Headaches or vision changes with high prolactin need prompt imaging.
Insulin resistance
Insulin is a hormone too, and it is often part of the picture. With insulin resistance, the body needs more insulin to keep blood sugar normal. It often comes with weight gain around the belly, dark velvety skin on the neck or armpits, skin tags, and in many women, PCOS. An A1C of 5.7 to 6.4 percent means prediabetes, and 6.5 percent or higher means diabetes.
Cortisol problems (rare)
True cortisol disorders are uncommon compared with thyroid problems and PCOS. Cushing syndrome, from too much cortisol, causes rapid weight gain in the face and upper back, wide purple stretch marks, easy bruising, muscle weakness and high blood pressure; the most common cause is steroid medicine such as prednisone taken for weeks or months. Addison disease, from too little cortisol, causes weight loss, low blood pressure, salt craving and darkening skin. Everyday stress does not cause either condition.
Low testosterone in women
Low testosterone in women is often blamed for low libido, but no blood level reliably diagnoses it in women, because levels vary and drop gradually with age over many years. Hormone guidelines support testosterone treatment only for low sexual desire after menopause that causes distress, once other causes such as relationship stress, low mood, medicines and vaginal dryness have been checked.
Hormone imbalance symptoms by life stage
Normal hormonal changes and true hormonal imbalances look different at each age, because your hormones shift with each stage. What to watch for:
- Teens and 20s: irregular periods, acne and extra hair growth point toward PCOS. Missing periods for 3 months or more with heavy exercise, low weight or stress can mean the brain has paused ovulation.
- 30s: period changes, trouble getting pregnant, fatigue and weight changes often lead to checking thyroid, prolactin and PCOS. After pregnancy, thyroid inflammation (postpartum thyroiditis) can cause symptoms in the first year.
- 40s: heavier or unpredictable periods, sleep problems, hot flashes and mood changes are most often perimenopause, though thyroid problems also become more common.
- 50s and beyond: night sweats, vaginal dryness and sleep changes are typical of menopause. Any bleeding after menopause needs to be checked.
Which blood tests help diagnose a hormone imbalance?
The right tests depend on your symptoms, age and cycle, and timing matters for some of them. Tests that commonly help:
- TSH, to check thyroid function. It can be drawn at any time of day.
- Pregnancy test, for any missed period during the reproductive years.
- Prolactin, if periods are missing or unpredictable or there is nipple discharge, usually drawn in the morning.
- Total and free testosterone, if PCOS is suspected, measured with an accurate lab method.
- Progesterone about 7 days before your expected period (day 21 of a 28-day cycle), to confirm ovulation.
- FSH, LH and estradiol early in the cycle (days 2 to 5), in selected cases such as missed periods before age 40.
- A1C or fasting glucose, and a cholesterol panel, if insulin resistance or PCOS is possible.
- Complete blood count and ferritin, because low iron causes many of the same symptoms.
Hormonal birth control changes most reproductive hormone levels, so these results can be hard to read while you are taking it. Single estrogen or FSH levels are usually not helpful in perimenopause, because both swing from day to day; perimenopause is mostly diagnosed from age, symptoms and period pattern.
What tests and labels do not help?
Saliva hormone tests for estrogen, progesterone and testosterone are not reliable. Results change with the time of day, food and collection method, and women's health and menopause experts do not recommend them for diagnosis or for guiding treatment. Large mail-in "hormone panels" also tend to produce abnormal-looking numbers that do not match symptoms.
"Adrenal fatigue" is not a recognized medical diagnosis. Hormone specialists do not accept it as a real condition, and there is no valid test for it. Tiredness that lasts for weeks is real, but it usually has a findable cause such as poor sleep, low iron, thyroid disease, depression or sleep apnea. Taking adrenal supplements can be harmful, because some contain real thyroid or steroid hormones.
"Hormone balancing" supplements and teas are not reviewed by the FDA for effectiveness before they are sold.
How do you fix a hormonal imbalance?
Treatment depends on the cause, so there is no single pill that balances hormones. Depending on what is found, options may include:
- Thyroid hormone medicine for an underactive thyroid, with a TSH recheck about 6 to 8 weeks after starting or changing the dose.
- Birth control pills or other hormonal options to regulate periods and lower androgen symptoms in PCOS.
- Metformin for insulin resistance or PCOS in selected patients.
- Menopausal hormone replacement therapy for hot flashes, night sweats and other menopause symptoms, with progesterone for anyone with a uterus.
- Medicine to lower prolactin, usually with an endocrinology referral.
- Diet changes, regular exercise, better sleep and losing a modest amount of weight, which may improve insulin resistance and period regularity in PCOS.
How long it takes depends on the condition. Thyroid levels are usually rechecked within 2 months, hormone therapy for hot flashes often works within a few weeks, and lifestyle changes for PCOS or insulin resistance usually take several months to show an effect.
When should you see a doctor?
Book a visit soon if you have:
- No period for 3 months or more (and you are not pregnant).
- Any bleeding after menopause.
- Very heavy bleeding, soaking a pad every hour for several hours.
- Milky nipple discharge, headaches or vision changes.
- Fast-growing facial or body hair or a deepening voice.
- Rapid weight gain with purple stretch marks or easy bruising.
- Depression, or thoughts of harming yourself. If you are in crisis, call or text 988.
How Dr. Munib approaches hormone imbalance symptoms
Dr. Munib is the primary care and hormone physician at The Pur Health, with 15+ years in Irvine. She starts with your symptoms rather than with a long list of tests, because hormone imbalances in women are usually easier to find that way. A visit usually includes:
- 1.A review of your cycle, symptoms, age, medicines, birth control, sleep, weight changes and family history.
- 2.Blood tests chosen for your situation and timed to your cycle when needed.
- 3.A plan based on the cause, such as thyroid treatment, PCOS care, menopause hormone therapy or lifestyle steps.
- 4.Referral to endocrinology or gynecology when imaging, a procedure or specialist care is needed.
Learn about hormone balancing at The Pur Health
Get your hormones checked in Irvine
If period changes, weight changes, poor sleep or mood changes are affecting your life, a visit can find what is really behind them. The Pur Health is at 114 Pacifica, Suite 280, Irvine, and is in-network with most PPO plans. Cash visits are $190 for new patients and $150 for returning patients. Call (949) 647-5234 to book.